![]() Ischemic heart disease (IHD) is a significant challenge among middle-aged individuals without diabetes. Additionally, sex differences may merit serious consideration when interpreting TG/HDL-C for assessing cardiovascular risks in clinical practice. Compared with metabolic syndrome, TG/HDL-C had a more powerful predictive value for IHD.Ĭonclusions: In Koreans without diabetes, an increased TG/HDL-C precedes future IHD. Compared with men, women showed higher HRs for the risk of incident IHD in the fourth quartile and 1.80, respectively). Results: During the follow-up period, 321 (2.0%) participants developed IHD. Using multivariate Cox proportional-hazards regression models, we prospectively examined the hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD over 50 months after baseline enrolment. ![]() Participants were classified based on the TG/HDL-C quartiles. Methods: We assessed 16,455 individuals (8,426 men and 8,029 women) without diabetes in a community-dwelling Korean cohort using National Health Insurance data. This study aimed to investigate the effects of the triglyceride to high-density lipid (HDL)-cholesterol ratio (TG/HDL-C), which could reflect insulin resistance from the beginning, on the incident risk of ischemic heart disease (IHD). 4Department of Family Medicine, Gangnam Severance Hospital, Seoul, South Koreaīackground: Early insulin resistance without diabetes can cause cardiovascular disease, which is a public health challenge.3Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul, South Korea.2Department of Family Medicine, Yonsei University College of Medicine, Seoul, South Korea. ![]() 1Department of Family Medicine, Yongin Severance Hospital, Seoul, South Korea.Byoungjin Park 1,2 † Dong Hyuk Jung 1,2 † Hye Sun Lee 3 Yong Jae Lee 2,4 * ![]()
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